Stigmas of dysembryogenesis of undifferentiated connective tissue dysplasia in bronchial asthma
https://doi.org/10.24884/1609-2201-2024-103-2-51-56
Abstract
Connective tissue dysplasia is a disturbance of its development during embryogenesis and the postnatal period due to genetically altered fibrillogenesis of the extracellular matrix. Undifferentiated connective tissue dysplasia (UCTD) includes a set of phenotypic characteristics that do not fit into any already known dysplastic syndrome or phenotype. It is this pathology of connective tissue that is widespread and is constantly encountered in the practice of doctors of various profiles, serving as the basis for the formation of various chronic diseases. As for bronchial asthma (BA), it is quite natural that studies have appeared to identify the characteristics of the course of BA with connective tissue dysplasia, primarily in children. It has been shown that asthma in children associated with connective tissue dysplasia has a number of clinical features: an earlier onset of the disease, a higher incidence of concomitant diseases, and a more severe course. The features of the course of bronchial asthma associated with connective tissue dysplasia in adults have been practically not studied. Our very first results from a study of adult patients with BA showed that in patients with a mild course of the disease, up to 3 stigmas of disembryogenesis were recorded, in patients with a moderate course - from 2 to 4, and in patients with a severe course - from 1 to 8 stigmas. Correlation analysis (the data was obtained on a small material, therefore we do not consider it statistically significant) provides a distinct basis for continuing the study. Thus, negative correlations have been identified between the presence of stigmas (myopia, dolichostenomelia, joint hypermobility, wide atrophic scars, varicose veins) and such an important characteristic of the disease as its controllability.
About the Authors
V. N. Mineev
Pavlov University
Russian Federation
Russian Federation
Valeriy N. Mineev, Professor of the Department of Hospital Therapy with a Course of Allergology and Immunology named after ac. M. V. Chernorutsky with clinic
6–8, L’va Tolstogo str., Saint Petersburg, 197022
L. I. Mamadayeva
Pavlov University
Russian Federation
Russian Federation
Laura I. Mamadaeva, 5th year student of the Faculty of Medicine
Saint Petersburg
References
1. Kadurina T. I., Gorbunova V. N. Contemporary concept of dysplasia of the connective tissue. Kazan medical journal. 2007;88(5–S):2–5. (In Russ).
2. Mineev V. N. Connective tissue dysplasia syndrome – a new look at old diseases. Novy`e Sankt-Peterburgskie vrachebny`e vedomosti. 2011;(1):19–36. (In Russ).
3. MakolkinV. I., Podzolkov V. I., Rodionov A. V. et al. Polymorphism of clinical symptoms of connective tissue dysplasia syndrome. Terapevticheskii arkhiv. 2004;(11):77–80. (In Russ).
4. Yakovlev V. M., Glotov A. V., Nechaeva G. I., Konenkov V. I. Clinical and immunological analysis of clinical variants of connective tissue dysplasia. Terapevticheskii arkhiv. 1994;(5):9–13. (In Russ).
5. Kondusova Y. V., Pochivalov A. V., Dombrovskiy S. V. Bronchial asthma associated with connective tissue dysplasia in children: clinical anamnesis peculiarities and rehabilitation measures. System analysis and management in biomedical systems. 2009;8(1):230–235. (In Russ).
6. Takushinova F. M. The occurrence frequency of fenotipic signs of connecting fabric dysplasia undifferentiated syndrome at children with bronchial asthma living in Stavropol. Journal of new medical technologies, e-edition. 2021(1). URL: http://medtsu.tula.ru/VNMT/Bulletin/E2012-1/3773.pdf (дата обращения: 10.08.20). (In Russ).
7. Nesterenko Z. V. Asthma symptoms in children with connective tissue Disorders: clinical features, complications. Medical news of North Caucasus. 2016;11(2.2):280–282. (In Russ). DOI: 10.14300/mnnc.2016.11055.
8. Bulatova E. M., Nesterenko Z. V. Community-aquired pneumonia in asthmatic children with different duration of inhaled corticosteroid therapy. Therapy. 2019;(7):69–73. (In Russ). DOI: 10.18565/therapy.2019.7.69-73.
9. Pochivalov A. V., Ivannikova A. S., Bugrimov D. Yu., Tsvetikova L. N. Effect of connective tissue dysplasia for a respiratory disease in children Belgorod State University Scientific bulletin. Medicine. Pharmacy. 2013;168(25,issue 24):45–49. (In Russ).
10. Nechaeva G. I., Vershinina M. V. Early diagnosis of obstructive syndrome in patients with signs of connective tissue dysplasia. Novy`e Sankt-Peterburgskie vrachebny`e vedomosti. 2003;(2):44–46. (In Russ).
11. Nechaeva G. I., Vershinina M. V., Govorova S. E. Respiratory pathology and connective tissue dysplasia: is a unified concept possible? Pulmonology. 2010;(3):5–10. (In Russ). DOI: 10.18093/0869-0189-2010-3-5-10.
12. Druk I. V. Bronchial asthma associated with connective tissue dysplasia: peculiarities of the course of the disease: abstract. cand. ... med. sci. Omsk, 2004. 24 p.
13. Mineev V. N., Lalaeva T. M., Trofimov V. I. Bronchial asthma and obesity: common mechanisms. Clinical medicine (Russian journal). 2012;89(4):4–10. (In Russ.).
14. Mineev V. N. Conception of asthma as membrane-receptor pathology. Immunopathology, Allergology, Infectology. 2005;(3):68–85. (In Russ).
15. Bulatov P. K., Fedoseev G. B. Bronchial asthma. The second edition, revised and supplemented. Leningrad, Medicine, Leningrad Department, 1975. (In Russ).
16. Guidelines of the russian scientific medical society of internal medicine on the diagnosis, treatment and rehabilitation of patients with the connective tissue displasia (first edition). Medical news of North Caucasus. 2018;13(1.2):137–209. (In Russ). DOI: 10.14300/mnnc.2018.13037.
17. Kytko O. V., Dydykina I. S., Sankova M. V. et al. Pathogenetic aspects of magnesium deficiency in connective tissue dysplasia syndrome. Problems of Nutrition. 2020;89(5):35–43. DOI: 10.24411/0042-8833-2020-10064. (In Russ).
18. Borzykh O. B., Petrova M. M., Karpova E. I., Shnayder N. A. Connective tissue disease in the practice of a cosmetologist and dermatologist. Features of diagnosis and management of patients. Vestnik Dermatiligy and Venereology. 2022;(98):19-32 DOI: 10.25208/vdv1232.
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For citations:
Mineev V.N., Mamadayeva L.I. Stigmas of dysembryogenesis of undifferentiated connective tissue dysplasia in bronchial asthma. New St. Petersburg Medical Records. 2024;(2):51-56. (In Russ.) https://doi.org/10.24884/1609-2201-2024-103-2-51-56
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