Problems of prescribing immunosupressive therapy to a rheumatological patient with chronic viral infection. Clinical case presentation
https://doi.org/10.24884/1609-2201-2024-103-2-77-81
Abstract
In rheumatological practice, overlap syndrome (“overlap-syndrome”) is often encountered, which is manifested by the presence of diagnostic signs of more than one of the six classic systemic autoimmune diseases. The presence of chronic viral infections significantly complicates drug therapy. The article presents the history of the disease of a 46-year-old patient who was diagnosed with an overlap syndrome in the form of a combination of idiopathic polymyositis with antisynthetase syndrome and rheumatoid arthritis. The complexity of treating the patient was determined by the identification of active chronic viral hepatitis C. A multidisciplinary approach to the management of the patient in compliance with the principles of rational pharmacotherapy is described.
About the Authors
M. D. TishkinaMaria D. Tishkina, rheumatologist
St. Petersburg, Bolshaya Podyacheskaya st., 30, 190068
D. A. Davydov
Russian Federation
Denis A. Davydov, rheumatologist of cardiology department No. 2, Clinic of the Research Institute of Rheumatology and Allergology
Saint Petersburg
E. A. Bruchkus
Russian Federation
Elena A. Bruchkus, rheumatologist, Head of Cardiology Department No. 2, Clinic of the Research Institute of Rheumatology and Allergology
Saint Petersburg
I. I. Nesterovich
Russian Federation
Irina I. Nesterovich, Dr. of Sci. (Med.), Professor of the Department of Hospital Therapy with a Course of Allergology and Immunology named after ac. M. V. Chernorutsky with clinic
Saint Petersburg
References
1. On the state of sanitary and epidemiological well-being of the Russian Federation in 2022: State report. M.: Federal Service for Supervision of Consumer Rights Protection and Human Welfare, 2023. (In Russ).
2. V. I. Mazurov, eds. Clinical rheumatology. 3rd edition, revised and expanded. Guide for doctors. Moscow, E-noto, 2021. 696 p. (In Russ).
3. Iaccarino L., Gatto M., Bettio S. et al. Overlap connective tissue disease syndromes. Autoimmun Rev. 2013;12(3):363–73. DOI: 10.1016/j.autrev.2012.06.004.
4. Sterling W. G. Rheumatology Secrets. Elsevier, 2019:765. ISBN 10: 0323641865 ISBN 13: 9780323641869
5. Oldroyd A. G. S., Lilleker J. B. et al. British Society for Rheumatology guideline on management of paediatric, adolescent and adult patients with idiopathic inflammatory myopathy. Rheumatology (Oxford). 2022;61(5):1760–1768. DOI: 10.1093/rheumatology/keac115.
6. Bottai M., Tjärnlund A., Santoni G. et al. EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report. RMD Open. 2017;3(2):e000507. DOI: 10.1136/rmdopen-2017-000507.
7. Marco J. L., Collins B. F. Clinical manifestations and treatment of antisynthetase syndrome. Best Pract Res Clin Rheumatol. 2020;34(4):101503. DOI: 10.1016/j.berh.2020.101503.
8. Schulte J. J., Husain A. N. Connective Tissue Disease Related Interstitial Lung Disease. Surg Pathol Clin. 2020;13(1):165–188. DOI: 10.1016/j.path.2019.11.005.
9. Ginting A. R., Tandiono V. Polymyositis concomitant with hepatitis B virus infection: Treatment challenges. Narra J. 2023;3(3):e514. DOI: 10.52225/narra.v3i3.514.
10. Xu S., Hu X., Wang J. et al. Polymyositis and dermatomyositis biomarkers. Clin Chim Acta. 2023;547:117443. DOI: 10.1016/j.cca.2023.117443.
11. Maundrell A., Proudman S., Limaye V. Prevalence of other connective tissue diseases in idiopathic inflammatory myopathies. Rheumatol Int. 2019;39(10):1777–1781. DOI: 10.1007/s00296-019-04411-8.
Review
For citations:
Tishkina M.D., Davydov D.A., Bruchkus E.A., Nesterovich I.I. Problems of prescribing immunosupressive therapy to a rheumatological patient with chronic viral infection. Clinical case presentation. New St. Petersburg Medical Records. 2024;(2):77-81. (In Russ.) https://doi.org/10.24884/1609-2201-2024-103-2-77-81