Preview

New St. Petersburg Medical Records

Advanced search

Thromboembolic complications in inflammatory bowel disease

https://doi.org/10.24884/1609-2201-2024-103-3-75-80

Abstract

Currently, there is an increase in the incidence and prevalence of inflammatory bowel diseases. A feature of this group of diseases, in addition to damage to the gastrointestinal tract, is the high frequency of extra-intestinal manifestations, among which thrombotic complications, life-threatening, multifactorial, with little studied pathogenesis, affecting  the therapy, are of particular interest. The practitioner is faced with the  issue  of  prescribing  antiplatelet  or  anticoagulant therapy to a specific patient with both a high risk of intestinal bleeding and a high risk of thrombosis and thromboembolic complications. The article presents the literature data and own observations on this topic. Modern recommendations for the management of patients are given. A clinical case demonstrating the peculiarities of managing a patient with Crohn's disease and thrombotic complications is presented.

About the Authors

O. Yu. Barysheva
Petrozavodsk State University; Republic hospital named after V. A. Baranov
Russian Federation

Olga Yu. Barysheva, Dr. of Sci. (Med.), Professor, Professor of the Department of Hospital Therapy from Medical Institute named after A. P. Zilber, Petrozavodsk State University; Head of Nephrology Department Republic hospital named after V. A. Baranov

Lenin Str., 33, 185910, Petrozavodsk, Republic of Karelia



A. M. Golubeva
Republic hospital named after V. A. Baranov
Russian Federation

Anna M. Golubeva, Gastroenterologist of Nephrology Department 

Petrozavodsk



References

1. Alkim H., Koksal A. R., Boga S. et al. Etiopathogenesis, prevention, and treatment of thromboembolism in inflammatory bowel disease. Clinical and Applied Thrombosis/Hemostasis. 2017;23(6):501–510. https://doi.org/10.1177/1076029616632906.

2. Bernstein C. N., Blanchard J. F., Houston D. S., Wajda A. The incidence of deep venous thrombosis and pulmonary embolism among patients with inflammatory bowel disease: a population-based cohort study. Thromb Haemost. 2001;85:430−4. https://pubmed.ncbi.nlm.nih.gov/11307809.

3. Olivera1 P. A., Zuily S., Kotze P. G. et al. International consensus on the prevention of venous and arterial thrombotic events in patients with infl bowel disease. Nat Rev Gastroenterol Hepatol. 2021;18(12):857–873. https://doi.org/10.1038/s41575-021-00492-8.

4. Kappelman M. D., Horvath-Puho E., Sandler R. S. et al. Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. Gut. 2011;60(7):937–43. https://doi.org/10.1136/gut.2010.228585.

5. Lishchinskaya A. A., Knyazev O. V., Kagramanova A. V. et al. Frequency and risk factors for thromboembolic complications in patients with infl bowel diseases. Ter. Arkh. 2022;94(2):172–179. (In Russ.). https://doi.org/10.26442/00403660.2022.02.201367.

6. Isene R., Bernklev T., Høie O. et al. Extraintestinal manifestations in Crohn’s disease and ulcerative colitis: results from a prospective, population-based European inception cohort. Scand J Gastroenterol. 2015;50:300−5. https://doi.org/10.3109/00365521.2014.991752.

7. Vegh Z., Kurti Z., Gonczi L. et al.Association of extraintestinal manifestations and anaemia with disease outcomes in patients with infl mmatory bowel disease. Scand J Gastroenterol. 2015;50:306−11. https://doi.org/10.3109/00365521.2016.1140807.

8. Weng M. T., Park S. H., Matsuoka K. et al. Incidence and risk factor analysis of thromboembolic events in EastAsian patients with infl matory bowel disease, a multinational collaborative study. Infl Bowel Dis. 2018;24:1791−800. https://doi.org/10.1093/ibd/izy058.

9. McCurdy J. D., Israel A., Hasan M. et al. Clinical predictive model for post-hospitalisation venous thromboembolism in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2019;49(12):1493–1501. https://doi.org/10.1111/apt.15286.

10. Sarlos P., Szemes K., Hegyi P. et al. Steroid but not biological therapy elevates the risk of venous thromboembolic events in inflammatory bowel disease: A meta-analysis. Journal of Crohn’s and Colitis. 2018;12(4):489–498. https://doi.org/10.1093/ecco-jcc/jjx162.

11. Nguyen G. C., Bernstein C. N., Bitton A. et al. Consensus statements on the risk, prevention, and treatment of venous thromboembolism in inflammatory bowel disease: Canadian Association of Gastroenterology. Gastroenterology. 2014;146:835–48. https://doi.org/10.1053/j.gastro.2014.01.042.


Review

For citations:


Barysheva O.Yu., Golubeva A.M. Thromboembolic complications in inflammatory bowel disease. New St. Petersburg Medical Records. 2024;(3):75-80. (In Russ.) https://doi.org/10.24884/1609-2201-2024-103-3-75-80

Views: 49


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1609-2201 (Print)