Role of TAS2R and transcription factor SREBP-2 in pathogenesis of respiratory diseases
https://doi.org/10.24884/1609-2201-2024-103-4-26-30
Abstract
More and more new data, concerning extraoral bitter taste receptors (TAS2R), appear now. Current data on SREBP-2, its role in cholesterol synthesis, participation of TAS2R in the local protective mechanisms in a ciliated epithelium of the respiratory tract and its activation by “quorum sensing” system molecules and its connection with the components of mucociliary clearance are presented.
The role of extraoral TAS2Rs and mechanisms of its regulation remain uncertain, that requires further research, including the field of respiratory pathology.
About the Authors
M. A. Nyoma
Pavlov University
Russian Federation
Russian Federation
Mikhail A. Nyoma - Cand. of Sci. (Med.), Associate Professor, M. Chernorutsky Hospital Therapy Department.
6‒8, L’va Tolstogo str., Saint Petersburg, 197022, +7-904-333-85-67
R. G. Murkina
Pavlov University
Russian Federation
Russian Federation
Rakhil G. Murkina - 1st year Resident.
Saint Petersburg
V. V. Sadovaya
Pavlov University
Russian Federation
Russian Federation
Victoria V. Sadovaya - 6th year student.
Saint Petersburg
V. N. Mineev
Pavlov University
Russian Federation
Russian Federation
Valery N. Mineev - Dr. of Sci. (Med.), Professor, M. Chernorutsky Hospital Therapy Department.
Saint Petersburg
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Review
For citations:
Nyoma M.A., Murkina R.G., Sadovaya V.V., Mineev V.N. Role of TAS2R and transcription factor SREBP-2 in pathogenesis of respiratory diseases. New St. Petersburg Medical Records. 2024;(4):26-30. (In Russ.) https://doi.org/10.24884/1609-2201-2024-103-4-26-30
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