TAS2R as components of the pathogenesis of respiratory diseases
https://doi.org/10.24884/1609-2201-2025-104-2-82-84
Abstract
The present work investigates the role of ectopic bitter taste receptors (TAS2R) in the pathogenesis of respiratory diseases. Data are provided on the mechanism of G-protein-mediated signal transduction from taste receptors. Participation of TAS2R in the local protective mechanisms in a ciliated epithelium of the respiratory tract and its activation by «quorum sensing» system molecules and its connection with the components of mucociliary clearance are presented. In addition, TAS2R receptors are also considered to be associated with allergic diseases, in particular – with bronchial asthma.
About the Authors
R. G. Murkina
Pavlov University
Russian Federation
Russian Federation
Rakhil G. Murkina, 1st year Resident of the Direction of General Doctor (Rheumatology)
6–8, L’va Tolstogo str., Saint Petersburg, 197022
M. A. Nyoma
Pavlov University
Russian Federation
Russian Federation
Mikhail A. Nyoma, Cand. of Sci. (Med.), Associate Professor of the Department of Hospital Therapy with the Course of Allergology and Immunology named after Acad. M. V. Chernorutsky with Clinic
Saint Petersburg
V. N. Mineev
Pavlov University
Russian Federation
Russian Federation
Valery N. Mineev, Dr. of Sci. (Med.), Professor of the Department of Hospital Therapy with the Course of Allergology and Immunology named after Acad. M. V. Chernorutsky with Clinic
Saint Petersburg
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Review
For citations:
Murkina R.G., Nyoma M.A., Mineev V.N. TAS2R as components of the pathogenesis of respiratory diseases. New St. Petersburg Medical Records. 2025;(2):82-84. (In Russ.) https://doi.org/10.24884/1609-2201-2025-104-2-82-84
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