Issues in diagnosis of pulmonary hypertension
https://doi.org/10.24884/1609-2201-2024-103-3-56-64
Abstract
Pulmonary hypertension (PH) – is a pathophysiological condition, which characterized by pressure elevation in pulmonary vascular bed without regard to its causes. Despite the great progress in understanding of etiology, pathophysiology and molecular mechanisms of PH, clinical diagnosis is still a great challenge for the medical practitioner. Lack of specific symptoms, demand of wide range of knowledge, necessity of well-equipped hospital – all these reasons lead to late diagnosis and treatment. In this article we provide brief information of clinical evaluation in case of PH and transthoracic echocardiography as a first step of instrumental examination towards precise diagnosis. .
About the Authors
A. A. ChurkoRussian Federation
Anna A. Churko, Assistant of the Department of Propaedeutics of Internal Diseases with clinic named after acad. M. D. Tushinksy
6–8, L’va Tolstogo str., Saint Petersburg, 197022
A. I. Nikonova
Russian Federation
Anastasia I. Nikonova, Senior Assistant of the Department of Propaedeutics of Internal Diseases with clinic named after acad. M. D. Tushinksy
Saint-Petersburg
L. A. Halilova
Russian Federation
Leyla A. Halilova, Senior Assistant of the Department of Propaedeutics of Internal Diseases with clinic named after acad. M. D. Tushinksy
Saint-Petersburg
I. Yu. Panina
Russian Federation
Irina Yu. Panina, Dr. of Sci. (Med.), Professor, Professor of the Department of Propaedeutics of Internal Diseases with clinic named after acad. M. D. Tushinksy
Saint-Petersburg
A. N. Kulikov
Russian Federation
Alexander N. Kulikov, Dr. of Sci. (Med.), Professor, Head of the Department of Propaedeutics of Internal Diseases with clinic named after acad. M. D. Tushinksy, Head of the Department of Functional Diagnostics, Director of the Scientific and Clinical Research Center
Saint-Petersburg
References
1. Lakhani S., Sunesara S., Ezhilarasan Santhi S. S. et al. Pulmonary hypertension: Revisiting the historical facts. IntechOpen, 2023. https://doi.org/10.5772/intechopen.1003984.
2. Von Romberg E. [Über Sklerose der Lungenarterie] On sclerosis of pulmonary arteries. Dtsch Arch Klin Med. 1891–1892;48:197–206. (In German).
3. Newman J. H. Pulmonary hypertension by the method of Paul Wood. Chest. 2020;158:1164–71. https://doi.org/10.1016/j.chest.2020.02.035.
4. Kovacs G., Olschewski H. The definition of pulmonary hypertension: history, practical implications and current controversies. Breathe. 2021;17:210076. https://doi.org/10.1183/20734735.0076-2021.
5. Nichols W. C., Koller D. L., Slovis B. et al. Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31–32. Nat Genet. 1997;15:277–280. https://doi.org/10.1038/ng0397-277.
6. Deng Z., Morse J. H., Slager S. L. et al. Familial primary pulmonary hypertension (Gene PPH1) is caused by mutations in the bone morphogenetic protein receptor–ii gene. The American Journal of Human Genetics. 2000;67:737–44. https://doi.org/10.1086/303059.
7. Kovacs G., Berghold A., Scheidl S., Olschewski H. Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review. European Respiratory Journal. 2009;34:888– 94. https://doi.org/10.1183/09031936.00145608.
8. Arkhipova O. A., Valieva Z. S., Martynyuk T. V. et al. features of pulmonary arterial hypertension in the russian register. Eurasian heart journal. 2014;(4):44–53. (In Russ.).
9. Ley L., Grimminger F., Richter M. et al. The early detection of pulmonary hypertension. Deutsches Ärzteblatt International. 2023. https://doi.org/10.3238/arztebl.m2023.0222.
10. Tartavoulle T. M., Karpinski A. C., Aubin A. et al. Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors. ERJ Open Res. 2018;4:00079–2017. https://doi.org/10.1183/23120541.00079-2017.
11. Neder J. A., Phillips D. B., O’Donnell D. E., Dempsey J. A. Excess ventilation and exertional dyspnoea in heart failure and pulmonary hypertension. Eur Respir J. 2022;60:2200144. https://doi.org/10.1183/13993003.00144-2022.
12. Sahni S., Verma S., Singh K. et al. Fatigue in pulmonary hypertension patients. Chest. 2016;150:1163A. https://doi.org/10.1016/j.chest.2016.08.1272.
13. Cabral D. R., Guimarães T., Almeida A. G. et al. Chest pain in a patient with pulmonary arterial hypertension. Revista Portuguesa de Cardiologia. 2022;41:73–80. https://doi.org/10.1016/j. repc.2020.05.021.
14. Chazova I. E., Martynyuk T. V., Shmalts A. A. et al. Eurasian guidelines for the diagnosis and treatment of pulmonary hypertension (2023). Eurasian heart journal. 2024;(1):6–85. (In Russ.).
15. Chazova I. E., Martynyuk T. V., Valieva Z. S. et al. eurasian clinical guidelines on diagnosis and treatment of pulmonary hypertension. Eurasian heart journal. 2020;(1):78–122. (In Russ.).
16. Simonneau G., Montani D., Celermajer D. S. et al. Haemodynamic defi tions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2019;53:1801913. https://doi.org/10.1183/13993003.019132018.
17. Humbert M., Kovacs G., Hoeper M. M. et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2023;61:2200879. https://doi.org/10.1183/13993003.00879-2022.
18. Chazova I. Y., Martynyuk T. V., Valieva Z. S. et al. Clinical and Instrumental Characteristics of Newly Diagnosed Patients with Various Forms of Pulmonary Hypertension according to the Russian National Registry. BioMed Research International. 2020;2020:1–12. https://doi.org/10.1155/2020/6836973.
19. Chazova I. E., Arkhipova O. A., Martynyuk T. V. Pulmonary arterial hypertension in Russia: six-year observation analysis of the National Registry. Terapevticheskii arkhiv. 2019;91:25–31. (In Russ.).
20. Ni J. R., Yan P. J., Liu S. D. et al. Diagnostic accuracy of transthoracic echocardiography for pulmonary hypertension: a systematic review and meta-analysis. BMJ Open. 2019;9:e033084. https://doi.org/10.1136/bmjopen-2019-033084
Review
For citations:
Churko A.A., Nikonova A.I., Halilova L.A., Panina I.Yu., Kulikov A.N. Issues in diagnosis of pulmonary hypertension. New St. Petersburg Medical Records. 2024;(3):56-64. (In Russ.) https://doi.org/10.24884/1609-2201-2024-103-3-56-64